Synthesis and Biological Assesment of Quinazolone Based Amide Linkage Containing Thiazolidinone and Their Derivatives

A number of substituted quinazolones are well known for their pharmacological activities like anti-inflammatory, antibacterial and analgesic etc. The present work deals with synthesis of quinazolone based thiazolidinone in order to enhance the biological properties. A Series of (2-(substituted phenyl)-4-oxothiazolidin-3-yl) -4(4-oxo-2-phenyl quinazolin-3(4H)-yl) benzamide (6a-6h) were synthesized in good yield. The structures of the compounds obtained have been established on the basis of Spectral (IR, H NMR, C NMR and Mass) data. The present study also involves in vivo antiinflammatory activity and in vitro antibacterial activity against few strains (gram positive and gram negative) of bacteria of synthesized compounds. Derivatives 6a, 6e and 6g exhibit promising anti-inflammatory and antibacterial activity with reference to standard drug Indomethacin and Ampicillin respectively. INTRODUCTION: 4-Thiazolidinones are the derivatives of thiazolidine which belong to an important group of heterocyclic compounds containing sulfur and nitrogen in a five member ring. The nucleus is also known as wonder nucleus 1 because it gives out different derivatives with all different types of biological activities such as antitubercular 2 , anti-microbial 3 , anti-cancer 4 , anticonvulsant 5 , antihistaminic 6 etc. Quinazolones and their derivatives are versatile nitrogen containing heterocyclic compounds which have been known as a promising class of biologically active compounds and has broad spectrum medicinal values such as analgesic 7 , antiinflammatory 8 , antibacterial 9 , anti-fungal 10 , anticancer 11 etc.